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Literature summary for 2.4.1.17 extracted from
- Human UDP-glucuronosyltransferase 2B7 (2001), Curr. Drug Metab., 2, 283-298.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| UGT2B7 expressed in COS-1 and COS-7 cells. UGT from both UGT1A and UGT1B families expressed in colon carcinoma cells Caco-2 | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | Km values for all endogenous substrates for UGT2B7 range from 0.006 to 0.1 mM | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| nuclear envelope | - |
Rattus norvegicus | 5635 | - |
| nuclear envelope | liver and intestine | Homo sapiens | 5635 | - |
| nuclear membrane | liver: isoforms UGT22B7 and UGT1A6 | Homo sapiens | 31965 | - |
| nucleus | in liver isoforms UGT2B7 and UGT1A6 | Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
overview | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| colon | - |
Homo sapiens | - |
| jejunum | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| small intestine | - |
Homo sapiens | - |
| small intestine | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
specific activity of several endogenous substrates by microsomal membranes for HK293 cells expressing UGT2B7 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-hydroxybiphenyl + UDP-glucuronate | UGT2B7H and UGT2B7Y inactive | Homo sapiens | UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide | - |
? |  |
| androsterone + UDPglucuronate | - |
Rattus norvegicus | UDP + androsterone O-glucuronide | - |
? | |
| androsterone + UDPglucuronate | glucuronidated by HGT2B7H and HGT2B7Y | Homo sapiens | UDP + androsterone O-glucuronide | - |
? | |
| codeine + UDPglucuronate | glucuronidated by HGT2B7H and HGT2B7Y | Homo sapiens | codeine-6-glucuronide + UDP | - |
? | |
| epitestosterone + UDP-glucuronate | glucuronidated by HGT2B7H and HGT2B7Y | Homo sapiens | UDP + epitestosterone O-glucuronide | - |
? | |
| estriol + UDPglucuronate | - |
Homo sapiens | UDP + estriol-16 alpha-glucuronide | - |
? | |
| additional information | Xenobiotic glucuronidation summarized | Homo sapiens | ? | - |
? | |
| additional information | Xenobiotic glucuronidation summarized | Rattus norvegicus | ? | - |
? | |
| additional information | 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids | Homo sapiens | ? | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | glucuronidated by HGT2B7H and HGT2B7Y at 3 and 6 hydroxy positions | Homo sapiens | UDP + morphine 3,6-diglucuronide | - |
? | |
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Release 2023.1 (January 2023)
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