Cloned (Comment) | Organism |
---|---|
expressed in baculovirus-infected insect cells and human B-lymphoblastoid cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
androsterone | inhibition of glucuronidation of troglitazone catalyzed by isozymes of UGT2 family | Homo sapiens | |
androsterone | Gunn rat strain, competitive inhibition of troglitazone glucuronidation | Rattus norvegicus | |
menthol | Gunn rat, non-competitive inhibition of troglitazone glucuronidation | Rattus norvegicus | |
testosterone | inhibition of glucuronidation of troglitazone catalyzed by isozymes of UGT2 family, other 8 steroids tested on hUGT2A1 | Homo sapiens | |
testosterone | Gunn rat, non-competitive inhibition of troglitazone glucuronidation | Rattus norvegicus | |
troglitazone | inhibition of bilirubin glucuronidation by UGT1A1 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.136 | - |
troglitazone | - |
Homo sapiens | |
0.136 | - |
troglitazone | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + UDPglucuronate | Homo sapiens | - |
UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | Rattus norvegicus | - |
UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | Rattus norvegicus Gunn | - |
UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | Rattus norvegicus Wistar | - |
UDP + bilirubin O-glucuronide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Wistar strain | - |
Rattus norvegicus | - |
Gunn strain | - |
Rattus norvegicus Gunn | - |
Gunn strain | - |
Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + UDPglucuronate | - |
Homo sapiens | UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | - |
Rattus norvegicus | UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | - |
Rattus norvegicus Gunn | UDP + bilirubin O-glucuronide | - |
? | |
bilirubin + UDPglucuronate | - |
Rattus norvegicus Wistar | UDP + bilirubin O-glucuronide | - |
? | |
troglitazone + UDPglucuronate | - |
Homo sapiens | UDP + troglitazone 6-O-glucuronide | - |
? | |
troglitazone + UDPglucuronate | Gunn and Wistar strains | Rattus norvegicus | UDP + troglitazone 6-O-glucuronide | - |
? | |
troglitazone + UDPglucuronate | Gunn and Wistar strains | Rattus norvegicus Gunn | UDP + troglitazone 6-O-glucuronide | - |
? | |
troglitazone + UDPglucuronate | Gunn and Wistar strains | Rattus norvegicus Wistar | UDP + troglitazone 6-O-glucuronide | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.009 | - |
androsterone | Gunn rat, inhibition of troglitazone glucuronidation | Rattus norvegicus | |
0.059 | - |
testosterone | Gunn rat, inhibition of troglitazone glucuronidation | Rattus norvegicus | |
0.112 | - |
testosterone | inhibition of 2-hydroxyestradiol glucuronidation | Homo sapiens | |
0.149 | - |
androsterone | inhibition of troglitazone glucuronidation | Homo sapiens |