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Literature summary for 2.4.1.17 extracted from

  • Zakim, D.; Vessey, D.A.
    The properties of uridine diphosphate glucuronyltransferase(s) which catalyse the synthesis of steroid glucuronides in microsomal fractions from guinea-pig liver (1976), Biochem. J., 157, 667-673.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
Mersalyl maximal activation towards estrone, estradiol and testosterone at 1 mM Cavia porcellus
Phospholipase A stimulation of glucuronidation of estradiol and estrone, inhibition of glucuronidation of testosterone in whole microsomes Cavia porcellus
UDP-N-acetylglucosamine no significant activation towards steroids as aglycones Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
Phospholipase A potentiates end-product inhibition in whole microsomes: inhibition of glucuronidation of testosterone, stimulation of glucuronidation of estradiol and estrone Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Cavia porcellus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ 1 mM, activation Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
 domestic guinea pig
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + UDPglucuronate
-
 Cavia porcellus UDP + estrone 3-O-glucuronide
-
 ?
testosterone + UDPglucuronate
-
 Cavia porcellus UDP + testosterone O-glucuronide
-
 ?