Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-methylcholanthrene | marked induction of hepatic microsomal UDPGT activity, sevenfold increase in the rate of 4-methylumbelliferone glucuronidation, more than 3fold increase towards 4-nitrophenol and fourfold increase towards 1-naphthol | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
52000 | - |
3-OH androgenic UDP-glucuronyltransferase, chromatofocusing and affinity chromatography | Rattus norvegicus |
56000 | - |
3-methylcholanthrene-inducible 4-nitrophenol UDP-glucuronyltransferase, chromatofocusing and affinity chromatography | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley rat | - |
Purification (Comment) | Organism |
---|---|
chromatofocusing and affinity chromatography on UDP-hexanolamine sepharose, three isoenzymes | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-naphthol + UDP-glucuronate | - |
Rattus norvegicus | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
4-methylumbelliferone + UDP-glucuronate | - |
Rattus norvegicus | UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide | - |
? | |
4-nitrophenol + UDP-glucuronate | 3-methylcholanthrene-inducible 4-nitrophenol UDP-glucuronyltransferase and 17-OH steroid UDP-glucuronyltransferase isoenzymes | Rattus norvegicus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
androsterone + UDPglucuronate | - |
Rattus norvegicus | UDP + androsterone O-glucuronide | - |
? | |
beta-estradiol + UDPglucuronate | - |
Rattus norvegicus | beta-estradiol-3-glucuronide + UDP | - |
? | |
etiocholanone + UDPglucuronate | 3-OH androgenic UDP-glucuronyltransferase isoenzyme | Rattus norvegicus | UDP + etiocholanone O-glucuronide | - |
? | |
testosterone + UDPglucuronate | isozyme 17-OH steroid UDPGT | Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | 4-nitrophenol UDP-glucuronyltransferase | Rattus norvegicus |
? | all values determined by SDS-PAGE | Rattus norvegicus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
-60 | - |
as pellets with a 1.15% KCl overlay, no apparent loss of activity for three months | Rattus norvegicus |