Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Triton X-100 | activation | Rattus norvegicus | |
UDP-N-acetylglucosamine | small activation towards 1-naphthol in MgCl2 activated microsomes | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UDP | end product mixed type inhibition towards UDPglucuronic acid and 1-naphthol in latent or partially MgCl2 activated microsomes | Rattus norvegicus | |
UDP-N-acetylglucosamine | full competitive inhibition towards UDPglucuronic acid, mixed-type inhibition towards 1-naphthol | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.012 | - |
testosterone | 1-naphthol added, in presence of 5 mM MgCl2 as activator | Rattus norvegicus | |
0.015 | - |
1-naphthol | no activator present | Rattus norvegicus | |
0.03 | - |
1-naphthol | presence of 50 mM MgCl2 as activator | Rattus norvegicus | |
0.067 | - |
1-naphthol | presence of 50 mM MgCl2, 0.1% Triton X-100 as activator | Rattus norvegicus | |
0.37 | - |
UDPglucuronate | 2 mM 1-naphthol added, in presence of 50 mM MgCl2 | Rattus norvegicus | |
0.59 | - |
UDPglucuronate | 0.2 mM 1-naphthol added, no activator present | Rattus norvegicus | |
0.71 | - |
UDPglucuronate | 0.2 mM 1-naphthol added, in presence of 50 mM MgCl2, 0.1% Triton X-100 as activator | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 50 mM, activation | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar strain | - |
Rattus norvegicus Wistar | - |
Wistar strain | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside | sequential bireactant mechanism | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-naphthol + UDP-glucuronate | - |
Rattus norvegicus | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
1-naphthol + UDP-glucuronate | - |
Rattus norvegicus Wistar | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
testosterone + UDPglucuronate | - |
Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? | |
testosterone + UDPglucuronate | - |
Rattus norvegicus Wistar | UDP + testosterone O-glucuronide | - |
? |