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Literature summary for 2.4.1.17 extracted from

  • Koster, A.S.; Noordhoek, J.
    Kinetic properties of the rat intestinal microsomal 1-naphthol:UDP-glucuronosyl transferase. Inhibition by UDP and UDP-N-acetylglucosamine (1983), Biochim. Biophys. Acta, 761, 76-85.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton X-100 activation Rattus norvegicus
UDP-N-acetylglucosamine small activation towards 1-naphthol in MgCl2 activated microsomes Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
UDP end product mixed type inhibition towards UDPglucuronic acid and 1-naphthol in latent or partially MgCl2 activated microsomes Rattus norvegicus
UDP-N-acetylglucosamine full competitive inhibition towards UDPglucuronic acid, mixed-type inhibition towards 1-naphthol Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
testosterone 1-naphthol added, in presence of 5 mM MgCl2 as activator Rattus norvegicus
0.015
-
1-naphthol no activator present Rattus norvegicus
0.03
-
1-naphthol presence of 50 mM MgCl2 as activator Rattus norvegicus
0.067
-
1-naphthol presence of 50 mM MgCl2, 0.1% Triton X-100 as activator Rattus norvegicus
0.37
-
UDPglucuronate 2 mM 1-naphthol added, in presence of 50 mM MgCl2 Rattus norvegicus
0.59
-
UDPglucuronate 0.2 mM 1-naphthol added, no activator present Rattus norvegicus
0.71
-
UDPglucuronate 0.2 mM 1-naphthol added, in presence of 50 mM MgCl2, 0.1% Triton X-100 as activator Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 50 mM, activation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar strain
-
Rattus norvegicus Wistar
-
Wistar strain
-

Reaction

Reaction Comment Organism Reaction ID
UDP-alpha-D-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside sequential bireactant mechanism Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
small intestine
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-naphthol + UDP-glucuronate
-
Rattus norvegicus naphth-1-yl-beta-D-glucuronide + UDP
-
?
1-naphthol + UDP-glucuronate
-
Rattus norvegicus Wistar naphth-1-yl-beta-D-glucuronide + UDP
-
?
testosterone + UDPglucuronate
-
Rattus norvegicus UDP + testosterone O-glucuronide
-
?
testosterone + UDPglucuronate
-
Rattus norvegicus Wistar UDP + testosterone O-glucuronide
-
?