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Literature summary for 2.4.1.165 extracted from

  • Malagolini, N.; Dall'Olio, F.; Guerrini, S.; Serafini-Cessi, F.
    Identification and characterization of the Sda beta1,4-N-acetylgalactosaminyltransferase from pig large intestine (1994), Glycoconj. J., 11, 89-95.
    View publication on PubMed
Search for more literature for 2.4.1.165

Activating Compound

Activating Compound Comment Organism Structure
n-octylglucoside 20-30% enhancement of activity with the proteins that behave as good acceptors: fetuin, alpha1-glycoprotein and human chorionic gonadotropin. 3fold enhancement of activity of the poor acceptor glycophorin Sus scrofa
Triton X-100 0.5%, 2fold increment in activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Triton X-100
-
 Homo sapiens
Triton X-100 0.5%, inhibition Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Sus scrofa
-
-
soluble large amounts of the enzyme is released in soluble form, particularly when CaCo-2 cells are maintained in culture for more than 3 weeks in order to ensure an higher degree of enterocyte differentiation Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens
Mn2+ required Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Homo sapiens
-
 UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Sus scrofa
-
 UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
cecum
-
 Homo sapiens
-
cecum
-
 Rattus norvegicus
-
cecum
-
 Sus scrofa
-
large intestine
-
 Homo sapiens
-
large intestine
-
 Sus scrofa
-
proximal colon
-
 Homo sapiens
-
proximal colon
-
 Sus scrofa
-

Storage Stability

Storage Stability Organism
-20 C, microsomal fraction, 1 year without significant loss of activity Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Homo sapiens ?
-
 ?
additional information the enzyme strictly recognizes the NeuAcalpha2,3Galbeta terminal sequence of N- and O-linked oligosaccharides bound to glycoproteins Sus scrofa ?
-
 ?
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 Homo sapiens UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
UDP-N-acetyl-D-galactosamine + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 Sus scrofa UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
-
 ?
UDP-N-acetyl-D-galactosamine + alpha1-acid glycoprotein
-
 Homo sapiens UDP + N-acetylgalactosaminyl-alpha1-acid glycoprotein
-
 ?
UDP-N-acetyl-D-galactosamine + alpha1-acid glycoprotein
-
 Sus scrofa UDP + N-acetylgalactosaminyl-alpha1-acid glycoprotein
-
 ?
UDP-N-acetyl-D-galactosamine + asialofetuin
-
 Homo sapiens UDP + N-acetylgalactosaminylasialofetuin
-
 ?
UDP-N-acetyl-D-galactosamine + asialofetuin
-
 Sus scrofa UDP + N-acetylgalactosaminylasialofetuin
-
 ?
UDP-N-acetyl-D-galactosamine + fetuin
-
 Homo sapiens UDP + N-acetylgalactosaminylfetuin
-
 ?
UDP-N-acetyl-D-galactosamine + fetuin
-
 Sus scrofa UDP + N-acetylgalactosaminylfetuin
-
 ?
UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin
-
 Homo sapiens UDP + N-acetylgalactosaminyl human chorionic gonadotropin
-
 ?
UDP-N-acetyl-D-galactosamine + human chorionic gonadotropin
-
 Sus scrofa UDP + N-acetylgalactosaminyl human chorionic gonadotropin
-
 ?
UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc
-
 Homo sapiens UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc
-
 ?
UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)Glc
-
 Sus scrofa UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc
-
 ?
UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc
-
 Sus scrofa UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc
-
 ?
UDP-N-acetyl-D-galactosamine + NeuAcalpha(2-3)Galbeta(1-4)GlcNAc i.e. 3'-sialyllactosamine Homo sapiens UDP + GalNAcbeta(1-4)(NeuAcalpha(2-3))Galbeta(1-4)Glc
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
 Sus scrofa