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Literature summary for 2.4.1.16 extracted from

  • Noureldin, N.A.; Kothayer, H.; Lashine, E.M.; Baraka, M.M.; Huang, Y.; Li, B.; Ji, Q.
    Design, synthesis and biological evaluation of novel quinazoline-2,4-diones conjugated with different amino acids as potential chitin synthase inhibitors (2018), Eur. J. Med. Chem., 152, 560-569 .
    View publication on PubMed
Search for more literature for 2.4.1.16

Inhibitors

Inhibitors Comment Organism Structure
1-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetyl)pyrrolidine-2-carboxylic acid 75.5% inhibition at 0.3 mg/ml Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)-3-(4-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetoxy)phenyl)propanoic acid 65.3% inhibition at 0.3 mg/ml Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)-3-phenylpropanoic acid
-
 Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)-4-(methylthio)butanoic acid
-
 Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)acetic acid
-
 Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)butanoic acid
-
 Saccharomyces cerevisiae
2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid
-
 Saccharomyces cerevisiae
3-(1H-imidazol-5-yl)-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid 61.5% inhibition at 0.3 mg/ml Saccharomyces cerevisiae
3-(1H-indol-3-yl)-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid
-
 Saccharomyces cerevisiae
3-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid
-
 Saccharomyces cerevisiae
3-hydroxy-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid
-
 Saccharomyces cerevisiae
3-methyl-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)butanoic acid
-
 Saccharomyces cerevisiae
4-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)butanoic acid 68.2% inhibition at 0.3 mg/ml Saccharomyces cerevisiae
4-methyl-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)pentanoic acid
-
 Saccharomyces cerevisiae
5-[(3,6,6-trimethylhept-4-yn-1-yl)amino]quinolin-2(1H)-one
-
 Saccharomyces cerevisiae
5-[(6,6-dimethylhepta-2,4-diyn-1-yl)(methyl)amino]-3,4-dihydroquinolin-2(1H)-one
-
 Saccharomyces cerevisiae
8-[(6,6-dimethylhepta-2,4-diyn-1-yl)(methyl)amino]-2H-1,4-benzoxazin-3(4H)-one
-
 Saccharomyces cerevisiae
Polyoxin B
-
 Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n Saccharomyces cerevisiae
-
 UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n Saccharomyces cerevisiae CGMCC2.145
-
 UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae CGMCC2.145
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n
-
 Saccharomyces cerevisiae UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
 ?
UDP-N-acetyl-alpha-D-glucosamine + [(1->4)-N-acetyl-beta-D-glucosaminyl]n
-
 Saccharomyces cerevisiae CGMCC2.145 UDP + [(1->4)-N-acetyl-beta-D-glucosaminyl]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosamine
-
 Saccharomyces cerevisiae UDP + 1,4-(N-acetyl-beta-D-glucosaminyl)2
-
 ?
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosamine
-
 Saccharomyces cerevisiae CGMCC2.145 UDP + 1,4-(N-acetyl-beta-D-glucosaminyl)2
-
 ?

Synonyms

Synonyms Comment Organism
CHS
-
 Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.166
-
 at pH 7.5 and 37°C Saccharomyces cerevisiae 2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)-3-(4-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetoxy)phenyl)propanoic acid
0.17
-
 at pH 7.5 and 37°C Saccharomyces cerevisiae Polyoxin B
0.18
-
 at pH 7.5 and 37°C Saccharomyces cerevisiae 1-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetyl)pyrrolidine-2-carboxylic acid
0.3
-
 at pH 7.5 and 37°C Saccharomyces cerevisiae 4-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)butanoic acid
0.3
-
 at pH 7.5 and 37°C Saccharomyces cerevisiae 3-(1H-imidazol-5-yl)-2-(2-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)acetamido)propanoic acid