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Literature summary for 2.4.1.16 extracted from
- Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents (2016), Eur. J. Med. Chem., 108, 166-176.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy) (phenoxy)phosphorylamino)-3-phenylpropanoate | - |
Candida tropicalis |  |
| methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy) (phenoxy)phosphorylamino)acetate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)acetate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | a noncompetitive inhibitor against chitin synthase | Candida tropicalis | |
| methyl 2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)acetate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-acetate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-acetate} | - |
Candida tropicalis | |
| methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate | - |
Candida tropicalis | |
| methyl 3-methyl-2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate | - |
Candida tropicalis | |
| methyl 3-methyl-2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate | - |
Candida tropicalis | |
| methyl 3-methyl-2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate | - |
Candida tropicalis | |
| methyl 3-methyl-2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate | - |
Candida tropicalis | |
| methyl 3-methyl-2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate | - |
Candida tropicalis | |
| additional information | synthesis and biological evaluation of phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents, overview | Candida tropicalis | |
| nikkomycin Z | - |
Candida tropicalis | |
| Polyoxin B | - |
Candida tropicalis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Candida tropicalis | |
| 3.86 | - |
UDP-N-acetyl-alpha-D-glucosamine | pH 7.5, 37°C | Candida tropicalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | Candida tropicalis | - |
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida tropicalis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Candida tropicalis | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CHS | - |
Candida tropicalis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Candida tropicalis |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Candida tropicalis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.096 | - |
methyl 2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | pH 7.5, 37°C | Candida tropicalis | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.08 | - |
pH 7.5, 37°C | Candida tropicalis | methyl 2-((2-(methyl(6-tert-butyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate | |
| 0.16 | - |
pH 7.5, 37°C | Candida tropicalis | Polyoxin B | |
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