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Literature summary for 2.4.1.16 extracted from

  • Guerriero, G.; Avino, M.; Zhou, Q.; Fugelstad, J.; Clergeot, P.H.; Bulone, V.
    Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs (2010), PLoS Pathog., 6, e1001070.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Saprolegnia monoica
functional expression in Pichia pastoris Saprolegnia monoica

Protein Variants

Protein Variants Comment Organism
additional information recombinant protein does not show in vitro activity Saprolegnia monoica

Inhibitors

Inhibitors Comment Organism Structure
nikkomycin Z competitive inhibition, presence of inhibitor leads to increased expression; competitive inhibition, presence of inhibitor leads to increased expression Saprolegnia monoica

Organism

Organism UniProt Comment Textmining
Saprolegnia monoica D7NQS8 isoform Chs1
-
Saprolegnia monoica D7NQS9 isoform Chs2
-

Source Tissue

Source Tissue Comment Organism Textmining
hypha hyphal tip Saprolegnia monoica
-

Subunits

Subunits Comment Organism
More isoform Chs1 protein contains N-terminal microtubule interacting and trafficking domains involved in protein recycling by endocytosis Saprolegnia monoica
More isoform Chs2 protein contains N-terminal microtubule interacting and trafficking domains involved in protein recycling by endocytosis Saprolegnia monoica

General Information

General Information Comment Organism
physiological function isoform Chs1 protein contains N-terminal microtubule interacting and trafficking domains involved in protein recycling by endocytosis. Chitin is vital for the micro-organisms despite its very low abundance in the cell walls. It is most likely synthesized transiently at the apex of the cells before cellulose, the major cell wall component in oomycetes Saprolegnia monoica
physiological function isoform Chs2 protein contains N-terminal microtubule interacting and trafficking domains involved in protein recycling by endocytosis. Chitin is vital for the micro-organisms despite its very low abundance in the cell walls. It is most likely synthesized transiently at the apex of the cells before cellulose, the major cell wall component in oomycetes Saprolegnia monoica