Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine | IC50: 1.6 mM | Saccharomyces cerevisiae | |
(2R,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine | IC50: 38 mM | Saccharomyces cerevisiae | |
(2S,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine | IC50: 4.0 mM | Saccharomyces cerevisiae | |
2,5-dideoxy-2,5-imino-D-glucitol | IC50: 5.7 mM | Saccharomyces cerevisiae | |
additional information | (2S,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine shows no inhibition at 8 mM. 2,5-dideoxy-2,5-imino-L-iditol shows no inhibition at 5 mM | Saccharomyces cerevisiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
X2180 strains | - |
Saccharomyces cerevisiae X2180 | - |
X2180 strains | - |
Synonyms | Comment | Organism |
---|---|---|
chitin synthase 1 | - |
Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1.6 | - |
IC50: 1.6 mM | Saccharomyces cerevisiae | (2R,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine | |
4 | - |
IC50: 4.0 mM | Saccharomyces cerevisiae | (2S,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine | |
5.7 | - |
IC50: 5.7 mM | Saccharomyces cerevisiae | 2,5-dideoxy-2,5-imino-D-glucitol | |
38 | - |
IC50: 38 mM | Saccharomyces cerevisiae | (2R,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine |