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Literature summary for 2.4.1.16 extracted from

  • Gautier-Lefebvre, I.; Behr, J.B.; Guillerm, G.; Muzard, M.
    Iminosugars as glycosyltransferase inhibitors: synthesis of polyhydroxypyrrolidines and their evaluation on chitin synthase activity (2005), Eur. J. Med. Chem., 40, 1255-1261.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine IC50: 1.6 mM Saccharomyces cerevisiae
(2R,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine IC50: 38 mM Saccharomyces cerevisiae
(2S,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine IC50: 4.0 mM Saccharomyces cerevisiae
2,5-dideoxy-2,5-imino-D-glucitol IC50: 5.7 mM Saccharomyces cerevisiae
additional information (2S,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine shows no inhibition at 8 mM. 2,5-dideoxy-2,5-imino-L-iditol shows no inhibition at 5 mM Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
X2180 strains
-
Saccharomyces cerevisiae X2180
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X2180 strains
-

Synonyms

Synonyms Comment Organism
chitin synthase 1
-
Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.6
-
IC50: 1.6 mM Saccharomyces cerevisiae (2R,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine
4
-
IC50: 4.0 mM Saccharomyces cerevisiae (2S,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine
5.7
-
IC50: 5.7 mM Saccharomyces cerevisiae 2,5-dideoxy-2,5-imino-D-glucitol
38
-
IC50: 38 mM Saccharomyces cerevisiae (2R,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine