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Literature summary for 2.4.1.16 extracted from

  • Yeager, A.R.; Finney, N.S.
    The first direct evaluation of the two-active site mechanism for chitin synthase (2004), J. Org. Chem., 69, 613-618.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethyl ester 1 mM, 32% inhibition, competitive. IC50: 2.2 mM Saccharomyces cerevisiae
[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-{2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethoxy}-ethyl ester 1 mM 45% inhibition. IC50: 11.8 mM Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.2
-
1 mM, 32% inhibition, competitive. IC50: 2.2 mM Saccharomyces cerevisiae [5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethyl ester
11.8
-
1 mM 45% inhibition. IC50: 11.8 mM Saccharomyces cerevisiae [5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-{2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethoxy}-ethyl ester