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Literature summary for 2.4.1.16 extracted from

  • Tatsuno, K.; Yamada-Okabe, H.; Takagi, M.; Arisawa, M.; Sudoh, M.
    Properties of yeast expressed Aspergillus nidulans chitin synthase B which is essential for hyphal growth (1997), FEMS Microbiol. Lett., 149, 279-284.
    View publication on PubMed
Search for more literature for 2.4.1.16

Activating Compound

Activating Compound Comment Organism Structure
GlcNAc
-
 Aspergillus nidulans

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae using the GAL1 promoter in a multicopy plasmid Aspergillus nidulans

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Aspergillus nidulans
EDTA
-
 Aspergillus nidulans
Polyoxin D
-
 Aspergillus nidulans
Zn2+
-
 Aspergillus nidulans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6
-
 UDP-GlcNAc
-
 Aspergillus nidulans

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for maximal activity Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n Aspergillus nidulans chitin synthase B is essential for hyphal growth UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
 chitin synthase B
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification activated by trypsin Aspergillus nidulans

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Aspergillus nidulans UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n chitin synthase B is essential for hyphal growth Aspergillus nidulans UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 activation by Mg2+ Aspergillus nidulans

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.5 pH 6.5: about 85% of maximal activity, pH 8.5: about 70% of maximal activity Aspergillus nidulans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.01
-
 Polyoxin D
-
 Aspergillus nidulans