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Literature summary for 2.4.1.16 extracted from
- Properties and cellular localization of chitin synthetase in Phycomyces blakesleeanus (1974), J. Biol. Chem., 249, 1973-1979.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ATP | 0.25 mM activates by 33%, concentrations up to 0.5 mM stimulate | Phycomyces blakesleeanus |  |
| GlcNAc | stimulates | Phycomyces blakesleeanus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | above 1 mM | Phycomyces blakesleeanus | |
| c3',5'-AMP | 2 mM, slight inhibition | Phycomyces blakesleeanus | |
| Polyoxin D | - |
Phycomyces blakesleeanus | |
| UDP | 0.5 mM, 28% inhibition | Phycomyces blakesleeanus | |
| UDPgalacturonic acid | 1 mM, about 20% inhibition | Phycomyces blakesleeanus | |
| UDPglucose | 1 mM, about 20% inhibition | Phycomyces blakesleeanus | |
| UDPglucuronic acid | 1 mM, about 20% inhibition | Phycomyces blakesleeanus | |
| UDPmannose | 1 mM, about 20% inhibition | Phycomyces blakesleeanus | |
| UDPxylose | 1 mM, about 20% inhibition | Phycomyces blakesleeanus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | - |
UDP-GlcNAc | - |
Phycomyces blakesleeanus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | - |
Phycomyces blakesleeanus | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | stimulates | Phycomyces blakesleeanus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Phycomyces blakesleeanus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mycelium | - |
Phycomyces blakesleeanus | - |
| sporangiospore | - |
Phycomyces blakesleeanus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n | - |
Phycomyces blakesleeanus | UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1 | chitin | ? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
- |
Phycomyces blakesleeanus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 27 | 42 | 50% of maximal activity at 17°C and at 42°C | Phycomyces blakesleeanus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Phycomyces blakesleeanus |
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