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Literature summary for 2.4.1.16 extracted from

  • Gow, L.A.; Selitrennikoff, C.P.
    Chitin synthetase of Neurospora crassa: inhibition by nikkomycin, polyoxin B, and UDP (1984), Curr. Microbiol., 11, 211-216.
No PubMed abstract available
Search for more literature for 2.4.1.16

Activating Compound

Activating Compound Comment Organism Structure
GlcNAc Km: 3.9 mM Neurospora crassa

Inhibitors

Inhibitors Comment Organism Structure
Nikkomycin linear competitive inhibitor Neurospora crassa
Polyoxin B
-
 Neurospora crassa
Polyoxin D linear competitive inhibitor Neurospora crassa
UDP linear competitive inhibitor Neurospora crassa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 8-20 mM, 6fold stimulation Neurospora crassa

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
-
 Neurospora crassa UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 Hepes buffer Neurospora crassa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 Nikkomycin
-
 Neurospora crassa
0.032
-
 Polyoxin B
-
 Neurospora crassa
0.8
-
 UDP
-
 Neurospora crassa