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Literature summary for 2.4.1.155 extracted from

  • Xu, Q.; Wang, W.; Qu, C.; Gu, J.; Yin, H.; Jia, Z.; Song, L.; Du, Y.
    Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure (2017), Carbohydr. Polym., 170, 241-246 .
    View publication on PubMed
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Application

Application Comment Organism
drug development COS may serve as a potential therapeutic candidate for the treatment of metastatic breast cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
stable overexpression of N-acetylglucosaminyltransferase V (GnT-V) in breast cancer MCF-10A cell line Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information chitosan oligosaccharides (COS) with a degree of polymerization (DP) of 2-6 inhibit breast epithelial cell migration through downregulation of GnT-V and its products, branched N-glycans. Antimetastatic potency of COS and the underlying mechanism, overview. COS may serve as a potential therapeutic candidate for the treatment of metastatic breast cancer. Glycosyltransferase-modified N-glycan structures can modulate cell migration and thereby cancer metastasis as well Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q09328
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Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell epithelial and metastatic Homo sapiens
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MCF-10A cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information branched N-glycans modified by GnT-V are evaluated by lectin blot analysis. The reactivities with Datura stramonium lectin (DSA) or leuko-agglutinating phytohemagglutinin (L4-PHA lectin), which specifically recognize, that branched N-glycans are clearly increased in the GnT-V transfectants compared to the control cells Homo sapiens ?
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Synonyms

Synonyms Comment Organism
GnT-V
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 Homo sapiens
Mgat5
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 Homo sapiens
N-acetylglucosaminyltransferase V
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 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens chitosan oligosaccharides (COS) inhibit the protein expression of GnT-V in a dose dependent manner down

General Information

General Information Comment Organism
malfunction GnT-V overexpression greatly promotes cell migration in the transfectants by using wound healing assay. But the induction in the cell migration is significantly suppressed by an addition of chitosan oligosaccharides (COS) Homo sapiens