Cloned (Comment) | Organism |
---|---|
gene MGAT5, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme downregulation in cancer cells by specific shRNA expression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09328 | gene MGAT5 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Colo-205 cell | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
colon cancer cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MKN-45 cell | - |
Homo sapiens | - |
additional information | quantitative enzyme expression analysis in cancer cells, overview | Homo sapiens | - |
WiDr cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GnT-V | - |
Homo sapiens |
N-acetylglucosaminyltransferase V | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme that catalyzes the formation of a beta1,6-N-acetylglucosamine side chain to a core mannosyl residue in N-linked glycoproteins. Besides its direct function of producing aberrant glycoproteins, it promotes cancer progression by its involvement in the stimulation of oncoproteins. Enzyme GnT-V guides the transcriptional activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) in cancer cells. The activated MT1-MMP expression has dual effects on cancer progression. It not only promotes proteolytic activity for cancer cells per se, but also leads to the activation of MMP-2. Consequently, the activation of the two MMPs triggered by GnT-V intensifies the invasive potential. Cancer invasion is stimulated by GnT-V-induced activation of both MT1-MMP and MMP-2 | Homo sapiens |