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Literature summary for 2.4.1.155 extracted from

  • Kamada, Y.; Mori, K.; Matsumoto, H.; Kiso, S.; Yoshida, Y.; Shinzaki, S.; Hiramatsu, N.; Ishii, M.; Moriwaki, K.; Kawada, N.; Takehara, T.; Miyoshi, E.
    N-Acetylglucosaminyltransferase V regulates TGF-beta response in hepatic stellate cells and the progression of steatohepatitis (2012), Glycobiology, 22, 778-787.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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Synonyms

Synonyms Comment Organism
GnT-V
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Mus musculus
N-acetylglucosaminyltransferase V
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Mus musculus

General Information

General Information Comment Organism
physiological function N-acetylglucosaminyltransferase V (GnT-V) regulates transforming growth factor-beta1 response in hepatic stellate cells and the progression of steatohepatitis through modulating lymphocyte and hepatic stellate cell functions. Excess expression of GnT-V enhances beta1-6GlcNAc branching of N-glycans in transgenic hepatic stellate cells. GnT-V enhances transforming growth factor-beta signaling but decreases collagen I expression in transgenic hepatic stellate cells Mus musculus