Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | - |
Mus musculus | - |
skin | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
GnT-V | - |
Mus musculus |
Mgat5 | - |
Mus musculus |
N-acetylglucosaminyltransferase-V | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Mgat5-deficient mouse skin is resistant to 12-O-tetradecanoyl phorbol-13-acetate-induced epidermal thickening. Cell surface epidermal growth factor receptor expression is decreased in Mgat5-deficient mouse keratinocytes | Mus musculus |
physiological function | a high enzyme expression in keratinocytes contributes to heparin-binding epidermal growth factor-like growth factor-mediated epidermal hyperproliferation by inhibiting endocytosis of epidermal growth factor receptors bearing beta1,6 N-acetylglucosamine on their N-glycans. The enzyme plays a role in epidermal homoeostasis, particularly in hyperproliferative conditions | Mus musculus |