Literature summary for 2.4.1.152 extracted from

Zhang, J.; Ju, N.; Yang, X; Chen, L.; Yu, C.
The alpha1,3-fucosyltransferase FUT7 regulates IL-1beta-induced monocyte-endothelial adhesion via fucosylation of endomucin (2018), Life Sci., 192, 231-237 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
EAhy 926 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
FUT7	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	treatment with inflammatory factors interleukin-1beta pronouncedly upregulates alpha1,3-fucosyltransferase VII gene (FUT7) mRNA and protein expression level in EA.hy926 endothelial cells	up

General Information

General Information	Comment	Organism
physiological function	FUT7 overexpression significantly promotes monocyte-endothelial adhesion, while FUT7 knockdown inhibits IL-1beta-induced monocyte-endothelial adhesion. Fucosylation of selectin ligand endomucin is directly involved in IL-1beta-induced monocyte-endothelial adhesion. p38 and extracellular signal-regulated kinase (ERK) MAPK signaling pathway are activated by IL-1beta, while inhibition of the p38/ERK signaling pathway decreases FUT7 expression level and IL-1beta-induced monocyte-endothelial adhesion	Homo sapiens

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Release 2023.1 (January 2023)