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Literature summary for 2.4.1.152 extracted from

  • Li, D.; Sun, H.; Bai, G.; Wang, W.; Liu, M.; Bao, Z.; Li, J.; Liu, H.
    alpha-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation (2018), Int. J. Mol. Med., 42, 2700-2708 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
MHCC-97 cell
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 Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens the mRNA and protein expression levels of FUT7 are high in the MHCC-97 cell line compared with levels in normal liver cells additional information

General Information

General Information Comment Organism
physiological function following FUT7 siRNA transfection, the expression of FUT7 is markedly downregulated. The synthesis of sialyl-Lewisx epitope is also inhibited, consistent with the downregulated expression of FUT7. MHCC-97 cell proliferation is also significantly inhibited following FUT7 siRNA transfection, which is correlated with suppression of the S-phase in cell cycle progression. The knockdown of FUT7 inhibits the activation of phospholipase Cgamma by inhibiting its translocation and phosphorylation Homo sapiens