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Literature summary for 2.4.1.152 extracted from

  • Gitlin, J.M.; Homeister, J.W.; Bulgrien, J.; Counselman, J.; Curtiss, L.K.; Lowe, J.B.; Boisvert, W.A.
    Disruption of tissue-specific fucosyltransferase VII, an enzyme necessary for selectin ligand synthesis, suppresses atherosclerosis in mice (2009), Am. J. Pathol., 174, 343-350.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development FucT-VII and the E- and P-selectin pathways may prove a fruitful therapeutic target in the prevention or treatment of atherosclerosis Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
FucT-VII-/-GFP+ bone marrow transplanted into lethally irradiated low-density lipoprotein receptor low density lipoprotein receptor mice or FucT-VII+/+GFP+ bone marrow into FucT-VII-/-, low density lipoprotein receptor double-mutant mice Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Synonyms

Synonyms Comment Organism
fucosyltransferase VII
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Mus musculus
FucT-VII
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Mus musculus

General Information

General Information Comment Organism
physiological function synthesis of E- and P-selectin ligands, as mediated by the rate-limiting enzyme FucT-VII, plays an important role in the pathogenesis of atherosclerosis Mus musculus