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Literature summary for 2.4.1.152 extracted from

  • Brito, C.; Escrevente, C.; Reis, C.A.; Lee, V.M.; Trojanowski, J.Q.; Costa, J.
    Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons (2007), J. Neurosci. Res., 85, 1260-1270.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information incubation with anti-Lex monoclonal antibody L5 leads to impaired adhesion of NT2N neurons to the surface matrix and inhibits neurite initiation Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Homo sapiens 5886
-
vesicular fraction TI-VAMP, compartment of NT2N neurons Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
x * 44000, glycosylated FUT9, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the final step in the biosynthesis of Lex is catalyzed by alpha3-fucosyltransferases with different specificites, which add a fucose residue to type II-based oligosaccharide chains, the alpha3-FUT activity in NT2 cells is the result of combined activities of FUT4 ad FUT9 whereas in NT2N cells only FUT9 participatein the Lex biosynthesis, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5Q0U2
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein FUT9 is a type II membrane protein with three potential N-glycosylation sites Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
Homo sapiens
-
NT2-N cell NTERA-2/cl.D1 cells are cultured and differentiated into NT2N neurons Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the final step in the biosynthesis of Lex is catalyzed by alpha3-fucosyltransferases with different specificites, which add a fucose residue to type II-based oligosaccharide chains, the alpha3-FUT activity in NT2 cells is the result of combined activities of FUT4 ad FUT9 whereas in NT2N cells only FUT9 participatein the Lex biosynthesis, overview Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 44000, glycosylated FUT9, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
fucosyltransferase IX
-
Homo sapiens
Fut9
-
Homo sapiens