Inhibitors | Comment | Organism | Structure |
---|---|---|---|
deoxyfuconojirimycin | modest inhibitor, causes 21% inhibition, synergism: combined with GDP at their Ki levels results in 80% inhibition, combined with GMP causes 50.4% inhibition | Homo sapiens | |
GDP | causes 22% inhibition | Homo sapiens | |
GDP-alpha-D-glucose | - |
Homo sapiens | |
GDP-alpha-D-mannose | - |
Homo sapiens | |
GDP-fucose | - |
Homo sapiens | |
GMP | causes 23% inhibition | Homo sapiens | |
GTP | potent inhibitor | Homo sapiens | |
Inosine diphosphate | potent inhibitor | Homo sapiens | |
L-fucal | modest inhibitor, causes 26% inhibition, combined with GDP causes 40% inhibition | Homo sapiens | |
additional information | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.025 | - |
GDP-fucose | LacNAcbeta-O-(CH2)5CO2CH3 as substrate | Homo sapiens | |
0.06 | - |
GDP-fucose | LacNAc as substrate | Homo sapiens | |
0.17 | - |
LacNAcbeta-O-(CH2)5CO2CH3 | - |
Homo sapiens | |
1.2 | - |
Co2+ | - |
Homo sapiens | |
6.1 | - |
Mn2+ | - |
Homo sapiens | |
6.7 | - |
Ca2+ | - |
Homo sapiens | |
8.6 | - |
Mg2+ | - |
Homo sapiens | |
8.8 | - |
LacNAc | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | alternative divalent metal cofactor | Homo sapiens | |
Co2+ | alternative divalent metal cofactor | Homo sapiens | |
Mg2+ | alternative divalent metal cofactor | Homo sapiens | |
Mn2+ | acts as electrophilic catalyst in the nonenzymatic hydrolysis of GDP-fucose | Homo sapiens | |
Zn2+ | no activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GDP-fucose + LacNAc | - |
Homo sapiens | GDP + ? | - |
? | |
GDP-fucose + LacNAcbeta-O-(CH2)5CO2CH3 | - |
Homo sapiens | GDP + ? | - |
? | |
additional information | catalyzes the transfer of the L-fucose moiety from guanosine diphosphate-beta-L-fucose to acceptor sugars to form biologically important fucoglycoconjugates, including sialyl Lewis x, the enzyme processes acceptor sugars with either oxygen or sulfur in the GlcNAc ring, but a similar sugar structure with nitrogen in the GlcNAc ring, is an inhibitor | Homo sapiens | ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | in both phosphate and cacodylate buffers | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0062 | - |
GDP-fucose | LacNAc as substrate | Homo sapiens | |
0.029 | - |
GDP | - |
Homo sapiens | |
0.031 | - |
GDP-fucose | LacNAcbeta-O-(CH2)5CO2CH3 as substrate | Homo sapiens | |
0.069 | - |
Inosine diphosphate | - |
Homo sapiens | |
0.29 | - |
GDP-alpha-D-mannose | - |
Homo sapiens | |
0.38 | - |
GDP-alpha-D-glucose | - |
Homo sapiens | |
0.7 | - |
GMP | - |
Homo sapiens | |
45 | - |
deoxyfuconojirimycin | - |
Homo sapiens | |
71 | - |
L-fucal | - |
Homo sapiens |