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Literature summary for 2.4.1.15 extracted from

  • Petzold, E.W.; Himmelreich, U.; Mylonakis, E.; Rude, T.; Toffaletti, D.; Cox, G.M.; Miller, J.L.; Perfect, J.R.
    Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans (2006), Infect. Immun., 74, 5877-5887.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose + D-glucose 6-phosphate Cryptococcus neoformans var. grubii both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target UDP + alpha,alpha-trehalose 6-phosphate
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Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans var. grubii Q6IVK9
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + D-glucose 6-phosphate
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Cryptococcus neoformans var. grubii UDP + alpha,alpha-trehalose 6-phosphate
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?
UDP-alpha-D-glucose + D-glucose 6-phosphate both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target Cryptococcus neoformans var. grubii UDP + alpha,alpha-trehalose 6-phosphate
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?

Synonyms

Synonyms Comment Organism
TPS1
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Cryptococcus neoformans var. grubii