Literature summary for 2.4.1.148 extracted from

Markine-Goriaynoff, N.; Gillet, L.; Karlsen, O.A.; Haarr, L.; Minner, F.; Pastoret, P.P.; Fukuda, M.; Vanderplasschen, A.
The core 2 beta-1,6-N-acetylglucosaminyltransferase-M encoded by bovine herpesvirus 4 is not essential for virus replication despite contributing to post-translational modifications of structural proteins (2004), J. Gen. Virol., 85, 355-367.

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Cloned(Commentary)

Cloned (Comment)	Organism
phylogenetic analysis, the gene Bo17, encoding the enzyme, is acquired from an ancestor of the African buffalo 1.5 million years ago	Bovine gammaherpesvirus 4

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of an enzyme-deletion mutant strain, the deletion does not alter the virus replication in vitro	Bovine gammaherpesvirus 4

Organism

Organism	UniProt	Comment	Textmining
Bovine gammaherpesvirus 4	-	gene Bo17, 9 strains, overview	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme is not essential for virus replication in vitro, but contributes to posttranslational modifications of structural proteins	Bovine gammaherpesvirus 4	?	-	?
UDP-N-acetyl-D-glucosamine + blood group i oligosaccharide	I branching activity	Bovine gammaherpesvirus 4	UDP + N-acetyl-beta-D-glucosaminyl-1,6-blood group i oligosaccharide	-	?
UDP-N-acetyl-D-glucosamine + core 1 oligosaccharide	-	Bovine gammaherpesvirus 4	UDP + core 2 oligosaccharide	-	?
UDP-N-acetyl-D-glucosamine + core 3 oligosaccharide	-	Bovine gammaherpesvirus 4	UDP + core 4 oligosaccharide	-	?
UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R	-	Bovine gammaherpesvirus 4	UDP + N-acetyl-beta-D-glucosaminyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,3)-N-acetyl-D-galactosaminyl-R	-	?

Synonyms

Synonyms	Comment	Organism
c2GnT-M	-	Bovine gammaherpesvirus 4
core 2 beta-1,6-N-acetylglucosaminyltransferase-M	-	Bovine gammaherpesvirus 4
More	the enzyme is a member of the beta-1,6-N-acetylglucosaminyltransferase gene family	Bovine gammaherpesvirus 4
mucin-type core 2 beta-1,6-N-acetylglucosaminyltransferase-M	-	Bovine gammaherpesvirus 4

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Release 2023.1 (January 2023)