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Literature summary for 2.4.1.147 extracted from

  • Bergstrom, K.; Fu, J.; Johansson, M.E.; Liu, X.; Gao, N.; Wu, Q.; Song, J.; McDaniel, J.M.; McGee, S.; Chen, W.; Braun, J.; Hansson, G.C.; Xia, L.
    Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice (2017), Mucosal Immunol., 10, 91-103 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.147

Protein Variants

Protein Variants Comment Organism
additional information generation of mutant mice lacking both intestinal core 1- and core 3-derived O-glycans (DKO), phenotype, overview. Generation of mutant C3GnT-/- Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] Mus musculus
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 UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3USF0
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-

Source Tissue

Source Tissue Comment Organism Textmining
colon mucosa Mus musculus
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epithelium
-
 Mus musculus
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intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
-
 Mus musculus UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
-
 ?

Synonyms

Synonyms Comment Organism
C3GnT
-
 Mus musculus
core 3 beta1,3-N-acetylglucosaminyltransferase
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 Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking intestinal core 1-derived O-glycans (IEC C1galt1-/-) develop spontaneous colitis primarily in the distal colon, whereas mice lacking both intestinal core 1- and core 3-derived O-glycans (DKO) develop spontaneous colitis in both distal and proximal colon. DKO mice show an early onset and more severe colitis than IEC C1galt1-/- mice. Antibiotic treatment restores the mucus layer and attenuates colitis in DKO mice. Mucins from DKO mice are more susceptible to proteolysis than wild-type mucins. C3GnT-/- mice exhibits no colitis phenotype without challenge. Analysis of colitis development in wild-type and mutant mice, overview. Loss of both core 1- and core 3-derived O-glycans affects mucus layer structure and colitis susceptibility throughout the colon. Antibiotic (NMVA) treatment improves mucus layer and reduces severity of colitis in DKO mice. Colitis is driven by bacterial-mucosal interactions following mucus barrier breach Mus musculus
metabolism core 1- and 3-derived O-glycans collectively contribute to the mucus barrier by protecting it from bacterial protease degradation Mus musculus
physiological function core 3 beta1,3-N-acetylglucosaminyltransferase (C3GnT), which controls the biosynthesis of core 3 O-glycans, is expressed mainly in the intestine and salivary glands Mus musculus