Literature summary for 2.4.1.145 extracted from

Nie, H.; Liu, X.; Zhang, Y.; Li, T.; Zhan, C.; Huo, W.; He, A.; Yao, Y.; Jin, Y.; Qu, Y.; Sun, X.L.; Li, Y.
Specific N-glycans of hepatocellular carcinoma cell surface and the abnormal increase of core-alpha-1,6-fucosylated triantennary Glycan via N-acetylglucosaminyltransferases-IVa regulation (2015), Sci. Rep., 5, 16007.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene MGAT4A, expression analysis	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	knockdown of GnT-IVa in 1668 cells and HepG2 cells by transfection with GnT-IVa shRNA. The level of NA3Fb decreases and M8 increases in knockdown GnT-IVa/1668 cells compared with GnT-IVa/NC after 48 h transfection. The scratch healing rates of the GnT-IVa/1668 group decreases more than the GnT-IVa/NC group. High expression of GnT-IVa leads to a higher level of NA3Fb in the HCC cell surface, and the downregulation of GnT-IVa may modulate cell invasion and migration through NA3Fb glycan	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UM21	gene MGAT4A	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
hepatocellular carcinoma cell	high expression of GnT-IVa, profiles and structures of the cell-surface N-glycan of hepatocellular carcinoma cells, high levels of NA3Fb, a core-alpha-1,6-fucosylated triantennary glycan, overview	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GnT-IVa	-	Homo sapiens
N-acetylglucosaminyltransferase IVa	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	aberrant glycosylation of the cell surface is associated with the malignant transformation of normal cells. Tumor-cell-surface glycans are closely associated with tumor-cell migration, adhesion, and metastasis4, profiling of specific cell surface N-glycans in hepatocellular carcinoma with clinical tissues (88 tumor and adjacent normal tissues) and the corresponding serum samples of hepatocellular carcinoma patients, overview. The level of core-alpha-1,6-fucosylated triantennary glycan (NA3Fb) increases both on the cell surface and in the serum samples of hepatocellular carcinoma patients, and mRNA and protein expression of N-acetylglucosaminyltransferase IVa (GnT-IVa), which is related to the synthesis of the NA3Fb, is substantially increased in hepatocellular carcinoma tissues. Knockdown of GnT-IVa leads to a decreased level of NA3Fb and decreased ability of invasion and migration in HCC cells. The high expression of GnT-IVa is the cause of the abnormal increase of NA3Fb on the HCC cell surface, which regulates cell migration	Homo sapiens
physiological function	the enzyme is involved in synthesis of tetra-antennary N-linked glycans. Cell surface glycans play an important role in intercellular and intracellular processes, including cell adhesion and development, cell recognition, and cancer development and metastasis. Changes in cell surface glycosylation modulate cellular activity	Homo sapiens

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Release 2023.1 (January 2023)