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Literature summary for 2.4.1.145 extracted from

  • Takamatsu, S.; Inoue, N.; Katsumata, T.; Nakamura, K.; Fujibayashi, Y.; Takeuchi, M.
    The relationship between the branch-forming glycosyltransferases and cell surface sugar chain structures (2005), Biochemistry, 44, 6343-6349.
    View publication on PubMed
Search for more literature for 2.4.1.145

Application

Application Comment Organism
synthesis it is necessary to select appropriate host cell lines according to their glycosyltransferases activity balance to produce glycoproteins with an objective sugar chain structure. The descibed method of grouping cell lines according to their glycosyltransferases activity balance is useful to select appropriate host cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R Homo sapiens the enzyme is involved in the branch formation of Asn-linked sugar chains UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell low activity Homo sapiens
-
BALL-1 cell
-
 Homo sapiens
-
BeWo cell high activity Homo sapiens
-
Caco-2 cell high activity Homo sapiens
-
EoL-1 cell low activity Homo sapiens
-
HeLa-S3 cell low activity Homo sapiens
-
Hep-G2 cell high activity Homo sapiens
-
HMCB cell low activity Homo sapiens
-
HuO-3N1 cell low activity Homo sapiens
-
KU-812 cell
-
 Homo sapiens
-
KU-812 cell low activity Homo sapiens
-
MOLT-4 cell high activity Homo sapiens
-
NAMALWA cell
-
 Homo sapiens
-
OS-RC-2 cell
-
 Homo sapiens
-
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R the enzyme is involved in the branch formation of Asn-linked sugar chains Homo sapiens UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 ?

Synonyms

Synonyms Comment Organism
GlcNAcTase-IV
-
 Homo sapiens
N-acetylglucosaminyltransferase-IV
-
 Homo sapiens