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Literature summary for 2.4.1.144 extracted from

  • Pinho, S.S.; Oliveira, P.; Cabral, J.; Carvalho, S.; Huntsman, D.; Gaertner, F.; Seruca, R.; Reis, C.A.; Oliveira, C.
    Loss and recovery of Mgat3 and GnT-III mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions (2012), PLoS ONE, 7, e33191.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the transfer of N-acetylglucosamine in a beta1,4 linkage to mannose on N-glycans forming a bisecting N-acetylglucosamine structure Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GnT-III
-
 Homo sapiens
MGAT3
-
 Homo sapiens
N-acetylglucosaminyltransferase-III
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens during epithelial-mesenchymal-transition, enzyme expression is dramatically decreased and later recoveres when cells return to an epithelial-like phenotype down

General Information

General Information Comment Organism
metabolism N-acetylglucosaminyltransferase-III-mediated glycosylation, specifically on E-cadherin, is a major component of the Epithelial-Mesenchymal-Transition /Mesenchymal-Epithelial-Transition mechanism signature Homo sapiens