Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.144 extracted from

  • Pinho, S.S.; Reis, C.A.; Paredes, J.; Magalhaes, A.M.; Ferreira, A.C.; Figueiredo, J.; Xiaogang, W.; Carneiro, F.; Gaertner, F.; Seruca, R.
    The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin (2009), Hum. Mol. Genet., 18, 2599-2608.
    View publication on PubMed
Search for more literature for 2.4.1.144

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-
additional information MCF-7/AZ cell Homo sapiens
-

Synonyms

Synonyms Comment Organism
GnT-III
-
 Homo sapiens
MGAT3
-
 Homo sapiens
N-acetylglucosaminyltransferase III
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens GnT-III knockdown in MCF-7/AZ cells through siRNA down
Homo sapiens knockdown of GnT-III, de-localization of E-cadherin and cytoplasmic accumulation, modification of N-glycosylation in E-cadherin down
Homo sapiens increase of enzyme expression by wild-type E-cadherin up
Homo sapiens wild-type E-cadherin regulates MGAT3 gene transcription resulting in increased GnT-III expression. GnT-III mRNA transcription levels in MDA-MB-435 cells transfected with E-cadherin wild-type are ca. 2fold higher than those in MDA-MB-435 mock cells up

General Information

General Information Comment Organism
malfunction knockdown of GnT-III by siRNA causes no alteration in expression levels of E-cadherin mRNA and protein, but induces alterations on E-cadherin cellular localization in MCF-7/AZ cells. GnT-III knockdown cells reveal a membrane de-localization of E-cadherin leading to its cytoplasmic accumulation and cause modifications of E-cadherin N-glycans catalyzed by GnT-III and GnT-V Homo sapiens
physiological function metastasis suppressor Homo sapiens