BRENDA - Enzyme Database
show all sequences of 2.4.1.135

Increased deposition of chondroitin/dermatan sulfate glycosaminoglycan and upregulation of beta1,3-glucuronosyltransferase I in pulmonary fibrosis

Venkatesan, N.; Ouzzine, M.; Kolb, M.; Netter, P.; Ludwig, M.S.; Am. J. Physiol. Lung Cell Mol. Physiol. 300, L191-L203 (2011)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
43000
-
x * 43000, SDS-PAGE
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
lung
-
Rattus norvegicus
-
lung fibroblast
-
Rattus norvegicus
-
Subunits
Subunits
Commentary
Organism
?
x * 43000, SDS-PAGE
Rattus norvegicus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
43000
-
x * 43000, SDS-PAGE
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
lung
-
Rattus norvegicus
-
lung fibroblast
-
Rattus norvegicus
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 43000, SDS-PAGE
Rattus norvegicus
Expression
Organism
Commentary
Expression
Rattus norvegicus
the enzyme is upregulated 3fold by 5 ng/ml transforming growth factor-beta1. Enzyme expression is increased in idiopathic pulmonary fibrosis, fibrotic rat lungs, and fibrotic lung fibroblasts
up
General Information
General Information
Commentary
Organism
metabolism
the enzyme is a key regulator and rate-limiting enzyme for the synthesis of GAG chains
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
metabolism
the enzyme is a key regulator and rate-limiting enzyme for the synthesis of GAG chains
Rattus norvegicus
Expression (protein specific)
Organism
Commentary
Expression
Rattus norvegicus
the enzyme is upregulated 3fold by 5 ng/ml transforming growth factor-beta1. Enzyme expression is increased in idiopathic pulmonary fibrosis, fibrotic rat lungs, and fibrotic lung fibroblasts
up
Other publictions for EC 2.4.1.135
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737068
Mikami
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Eisenia andrei
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e0118587
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2
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721257
Venkatesan
Increased deposition of chondr ...
Rattus norvegicus
Am. J. Physiol. Lung Cell Mol. Physiol.
300
L191-L203
2011
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721465
Gogate
Hypoxic regulation of beta-1,3 ...
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Arthritis Rheum.
63
1950-1960
2011
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9824-9834
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687722
Tone
2-o-phosphorylation of xylose ...
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676957
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Homo sapiens
Protein Expr. Purif.
47
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1
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677013
Fondeur-Gelinotte
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15
1667-1678
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Phosphorylation and sulfation ...
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8
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659435
Wei
Temperature-sensitive glycosam ...
Cricetulus griseus
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279
5693-5698
2004
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1
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1
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657737
Negishi
Glucosaminylglycan biosynthesi ...
Homo sapiens
Biochem. Biophys. Res. Commun.
303
393-398
2003
-
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1
-
-
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1
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1
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659240
Gulberti
The functional glycosyltransfe ...
Homo sapiens
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278
32219-32226
2003
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1
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9
-
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4
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3
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393085
Pedersen
Crystal structure of beta 1,3- ...
Homo sapiens
J. Biol. Chem.
277
21869-21873
2002
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1
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1
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659180
Ouzzine
The donor substrate specificit ...
Homo sapiens
J. Biol. Chem.
277
25439-25445
2002
-
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1
-
3
-
1
5
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1
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2
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7
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1
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5
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1
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7
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657807
Kitagawa
Human glycosaminoglycan glucur ...
Homo sapiens
Biochem. J.
358
539-546
2001
-
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1
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1
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2
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1
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393087
Pedersen
Heparan/chondroitin sulfate bi ...
Homo sapiens
J. Biol. Chem.
275
34580-34585
2000
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1
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1
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2
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393088
Ouzzine
Structure/function of the huma ...
Homo sapiens
J. Biol. Chem.
275
28254-28260
2000
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1
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2
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1
3
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2
1
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4
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1
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1
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1
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393086
Tone
Characterization of recombinan ...
Homo sapiens
FEBS Lett.
459
415-420
1999
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1
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2
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2
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2
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393090
Bai
Chinese hamster ovary cell mut ...
Cricetulus griseus
J. Biol. Chem.
274
13017-13024
1999
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659141
Wei
Formation of HNK-1 determinant ...
Cricetulus griseus
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1999
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393089
Kitagawa
Molecular cloning and expressi ...
Homo sapiens
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6615-6618
1998
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393084
Helting
Biosynthesis of heparin. Solub ...
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1
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1
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393083
Helting
Biosynthesis of chondroitin su ...
Gallus gallus
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244
2799-2805
1969
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2
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6
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