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Literature summary for 2.4.1.13 extracted from
- The signal metabolite trehalose-6-phosphate inhibits the sucrolytic activity of sucrose synthase from developing castor beans (2018), FEBS Lett., 592, 2525-2532 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose 6-phosphate | 1 mM D-glucose 6-phosphate slightly decreases the enzyme activity by less than 20% | Ricinus communis |  |
| additional information | 1 mM D-glucose 1-phosphate has no effect on the enzyme | Ricinus communis | |
| trehalose 6-phosphate | more than 90% inhibition at 1 mM | Ricinus communis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
sucrose | in the presence of 0.2 mM trehalose 6-phosphate, at pH 7.0 and 25°C | Ricinus communis | |
| 0.037 | - |
sucrose | in the absence of trehalose 6-phosphate, at pH 7.0 and 25°C | Ricinus communis | |
| 0.052 | - |
UDP | in the presence of 0.2 mM trehalose 6-phosphate, at pH 7.0 and 25°C | Ricinus communis | |
| 0.061 | - |
UDP | in the absence of trehalose 6-phosphate, at pH 7.0 and 25°C | Ricinus communis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1 mM used in assay conditions | Ricinus communis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NDP-alpha-D-glucose + D-fructose | Ricinus communis | - |
NDP + sucrose | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ricinus communis | - |
cultivar Baker 296 | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylated at Ser11 by the Ca2+-dependent protein kinase CDPK2 | Ricinus communis |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Ricinus communis | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NDP-alpha-D-glucose + D-fructose | - |
Ricinus communis | NDP + sucrose | - |
r | |
| UDP + sucrose | - |
Ricinus communis | UDP-alpha-D-glucose + D-fructose | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | 4 * 93000, SDS-PAGE | Ricinus communis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SUS1 | - |
Ricinus communis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.201 | - |
at pH 7.0 and 25°C | Ricinus communis | trehalose 6-phosphate | |
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Release 2023.1 (January 2023)
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