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Literature summary for 2.4.1.129 extracted from

  • Lovering, A.L.; De Castro, L.; Strynadka, N.C.
    Identification of dynamic structural motifs involved in peptidoglycan glycosyltransfer (2008), J. Mol. Biol., 383, 167-177.
    View publication on PubMed
Search for more literature for 2.4.1.129

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta lambdaDE3 cells Staphylococcus aureus

Crystallization (Commentary)

Crystallization (Comment) Organism
sitting drop vapor diffusion method, using 100 mM HEPES, pH 7.5, 2 M ammonium sulfate, 20% (v/v) ethylene glycol and 0.28 mM lauryldimethylamine oxide Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
Moenomycin
-
 Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus NCTC 8325
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-affinity column chromatography, gel filtration, and Mono Q ion-exchange chromatography Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Staphylococcus aureus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
 Staphylococcus aureus NCTC 8325 [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
PBP2
-
 Staphylococcus aureus
penicillin-binding protein 2 bifunctional peptidoglycan glycosyltransferase/transpeptidase Staphylococcus aureus