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Literature summary for 2.4.1.129 extracted from

  • Wang, T.S.; Manning, S.A.; Walker, S.; Kahne, D.
    Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths (2008), J. Am. Chem. Soc., 130, 14068-14069.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
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Escherichia coli
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-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
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Escherichia coli [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate for isoform PBP1B, the limiting length of produced glycan chains is about 50 disaccharide units, whereas it is about 30 disaccharide units for isoform PBP1A ?
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
Staphylococcus aureus [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate for isoform PBP2, the limiting length of produced glycan chains is about 15 disaccharide units ?
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
Enterococcus faecalis [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate for isoform PBP2A, the limiting length of produced glycan chains is about 15 disaccharide units ?

Synonyms

Synonyms Comment Organism
PBP1a isoform Escherichia coli
PBP1b isoform Escherichia coli
PBP2 isoform Staphylococcus aureus
PBP2A isoform Enterococcus faecalis
penicillin-binding protein
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Staphylococcus aureus
penicillin-binding protein
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Escherichia coli
penicillin-binding protein
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Enterococcus faecalis
PGT
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Staphylococcus aureus
PGT
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Escherichia coli
PGT
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Enterococcus faecalis