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Literature summary for 2.4.1.129 extracted from

  • Ramachandran, V.; Chandrakala, B.; Kumar, V.P.; Usha, V.; Solapure, S.M.; de Sousa, S.M.
    Screen for inhibitors of the coupled transglycosylase-transpeptidase of peptidoglycan biosynthesis in Escherichia coli (2006), Antimicrob. Agents Chemother., 50, 1425-1432.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
activity of PBP1a or PBP1b can be measured in membranes by cloning the PBP into an Escherichia coli ponB::Spcr strain Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Moenomycin coupled transglycosylasetranspeptidase Escherichia coli
nisin
-
Escherichia coli
penicillin coupled transglycosylasetranspeptidase Escherichia coli
tunicamycin
-
Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol PBP1a and PBP1b have both transglycosylase and transpeptidase activity Escherichia coli [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
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Synonyms

Synonyms Comment Organism
PBP1a the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
PBP1b the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
penicillin-binding protein 1a the enzyme has both transglycosylase and transpeptidase activity Escherichia coli
penicillin-binding protein 1B the enzyme has both transglycosylase and transpeptidase activity Escherichia coli