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Literature summary for 2.4.1.11 extracted from

  • Ros, S.; Garcia-Rocha, M.; Dominguez, J.; Ferrer, J.C.; Guinovart, J.J.
    Control of liver glycogen synthase activity and intracellular distribution by phosphorylation (2009), J. Biol. Chem., 284, 6370-6378.
    View publication on PubMed
Search for more literature for 2.4.1.11

Cloned(Commentary)

Cloned (Comment) Organism
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 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
S10A phosphorylation mutant. Mutation does not cause singnificant changes in the activation state Rattus norvegicus
S640A phosphorylation mutant, moderate increase in the activity ratio Rattus norvegicus
S644A phosphorylation mutant, moderate increase in the activity ratio Rattus norvegicus
S648A phosphorylation mutant. Mutation does not cause singnificant changes in the activation state Rattus norvegicus
S652A phosphorylation mutant. Mutation does not cause singnificant changes in the activation state Rattus norvegicus
S656A phosphorylation mutant. Mutation does not cause singnificant changes in the activation state Rattus norvegicus
S7A phosphorylation mutant, large increase in the activity ratio both in soluble and insoluble fraction. Enzyme is almost fully active and able to induce glycogen deposition in primary hepatocytes incubated in the absence of glucose and in FTO2B cells, a cell line that does not normallysynthesize glycogen. Mutation is also sufficient to trigger the aggregation and translocation of liver glycogen synthase from the cytoplasm to the hepatocyte cell cortex in the absence of glucose Rattus norvegicus
S7A/E509A phosphorylation and active site mutant. Translocation of liver glycogen synthase from the cytoplasm to the hepatocyte cell cortex in the absence of glucose is not observed Rattus norvegicus
S7A/S10A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus
S7A/S640A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus
S7A/S644A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus
S7A/S648A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus
S7A/S652A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus
S7A/S656A phosphorylation double mutant, large increase in the activity ratio both in soluble and insoluble fraction Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
FTO-2B cell
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 Rattus norvegicus
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liver
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 Rattus norvegicus
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