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Literature summary for 2.4.1.11 extracted from

  • Westphal, S.A.; Nuttall, F.Q.
    Comparative characterization of human and rat liver glycogen synthase (1992), Arch. Biochem. Biophys., 292, 479-486.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Homo sapiens
glucose 6-phosphate synthase D, i.e. phosphorylated form, is glucose 6-phosphate dependent, synthase I, i.e. dephosphorylated form, is glucose 6-phosphate independent, interconversion of D and I forms and vice versa Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information dependence on glucose 6-phosphate concentration Homo sapiens
additional information
-
additional information dependence on glucose 6-phosphate concentration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-glucose + glycogen Homo sapiens
-
glycogen + UDP
-
?
UDP-glucose + glycogen Rattus norvegicus
-
glycogen + UDP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
40
-
-
Homo sapiens
40
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-glucose + glycogen
-
Homo sapiens glycogen + UDP
-
?
UDP-glucose + glycogen
-
Rattus norvegicus glycogen + UDP
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30 40
-
Homo sapiens
30 40
-
Rattus norvegicus

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
additional information
-
human enzyme has no activity above 50°C, rat enzyme is active up to at least 60°C Homo sapiens
additional information
-
human enzyme has no activity above 50°C, rat enzyme is active up to at least 60°C Rattus norvegicus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
inactivation above Homo sapiens
60
-
inactivation above Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 9 synthase I Homo sapiens
7 9 synthase I Rattus norvegicus
8.8
-
synthase D Homo sapiens
8.8
-
synthase D Rattus norvegicus

pH Stability

pH Stability pH Stability Maximum Comment Organism
additional information
-
overview: stability in various buffer systems Homo sapiens
additional information
-
overview: stability in various buffer systems Rattus norvegicus