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Literature summary for 2.4.1.102 extracted from

  • Brockhausen, I.; Kuhns, W.; Schachter, H.; Matta K.L.; Sutherland, D.R.; Baker, M.A.
    Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Galbeta3GalNAcalpha-R (GlcNAc to GalNAc) beta(1,6)-N-acetylglucosaminyltransferase in leikemic cells (1991), Cancer Res., 51, 1257-1263.
    View publication on PubMed
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Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ not required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
acute myeloid leukemia cell acute myeloid leukemia blast cell line Homo sapiens
-
acute myeloid leukemia cell 18fold increased level compared to normal granulocytes Homo sapiens
-
CML cell chronic myelogenous leukemia granulocyte cell line Homo sapiens
-
CML cell 4fold increased level compared to normal granulocytes Homo sapiens
-
granulocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000048
-
 normal granulocytes Homo sapiens
0.00002
-
 CML granulocytes Homo sapiens
0.000087
-
 AML cells Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-benzyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-benzyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R large scale preparation Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens