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Literature summary for 2.4.1.102 extracted from

  • Schwientek, T.; Yeh, J.C.; Levery, S.B.; Keck, B.; Merkx, G.; Van Kessel, A.G.; Fukuda, M.; Clausen, H.
    Control of O-glycan branch formation: molecular cloning and characterization of a novel thymus-associated core 2 beta1,6-N-acetylglucosaminyltransferase (2000), J. Biol. Chem., 275, 11106-11113.
    View publication on PubMed
Search for more literature for 2.4.1.102

Cloned(Commentary)

Cloned (Comment) Organism
cloning and expression of isozyme 3 in Spodoptera frugiperda Sf9 insect cells via baculovirus infection, secretion of the enzyme Homo sapiens
coexpression of isozyme 3 with leukosialin as substrate in CHO cells for in vivo activity assay of the enzyme Homo sapiens
DNA sequence determination and analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular secretion into medium of the recombinant enzyme from Sf9 cells Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O95395 isozyme 2
-
Homo sapiens Q02742 isozyme 1
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Homo sapiens Q9P109 isozyme 3
-

Source Tissue

Source Tissue Comment Organism Textmining
colon low content Homo sapiens
-
leukocyte peripheral blood Homo sapiens
-
ovary low content Homo sapiens
-
peripheral blood
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
spleen low content Homo sapiens
-
testis low content Homo sapiens
-
thymus high content Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no activity human transferrin and IgG, N-acetylgalactosamine, core 3 substrates Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + asialo-alpha1 acid glycoprotein no activity Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + asialo-submaxillary mucin low activity Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + asialo-submaxillary mucin bovine asialo-submaxillary mucin Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + asialofetuin
-
 Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + asialoglycophorin A best substrate Homo sapiens ?
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-methylumbelliferyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-methylumbelliferyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-p-nitrophenyl
-
 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R substrate specificity Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R i.e. core class 1, R: polypeptide Homo sapiens UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R i.e. core class 2 ?
UDP-N-acetyl-D-glucosamine + fetuin no activity Homo sapiens ?
-
 ?