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Literature summary for 2.4.1.101 extracted from

  • Fritz, T.A.; Gabb, M.M.; Wei, G.; Esko, J.D.
    Two N-acetylglucosaminyltransferases catalyze the biosynthesis of heparan sulfate (1994), J. Biol. Chem., 269, 28809-28814.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
CHAPS slight activation Cricetulus griseus
Triton X-100 slight activation Cricetulus griseus
Zwittergent 3-12 slight activation Cricetulus griseus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.036
-
UDP-N-acetyl-D-glucosamine
-
Cricetulus griseus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Cricetulus griseus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ can substitute Mn2+ Cricetulus griseus
Mn2+ requirement Cricetulus griseus
Mn2+ can also use Ca2+ Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Cricetulus griseus enzyme initiates the biosynthesis of heparan sulfate ?
-
?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
wild-type and mutant cell lines
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell wild-type and mutant F6 and F8 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0000002
-
wild-type S49 cell Cricetulus griseus
0.00000084
-
wild-type CHO cell Cricetulus griseus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme initiates the biosynthesis of heparan sulfate Cricetulus griseus ?
-
?
UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
-
Cricetulus griseus UDP + alpha-D-mannosyl-1,6-(alpha-D-mannosyl-1,3)-alpha-D-mannosyl-1,6-(N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-1,4-N-acetyl-D-glucosaminyl-R
-
?
UDP-N-acetyl-D-glucosamine + GlcUAcbeta1-3Galbeta1-O-naphthalenemethanol synthetic substrate Cricetulus griseus ?
-
?

Synonyms

Synonyms Comment Organism
GlcNAc-T I
-
Cricetulus griseus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5 8 broad optimum Cricetulus griseus