Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucose | physiological inhibitor | Oryctolagus cuniculus | |
additional information | computationally motivated synthesis, using N-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-tetrazole-5-carboxamide as starting material, and enzyme kinetic evaluation of N-(beta-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors, overview. No inhibition by 3b and 4b. Ki values are calculated from the IC50 values by the ChengPrusoff equation: Ki = IC50/(1 + [S]/Km). Comparison of the relative energies of different tautomers and conformations of the 1,2,4-triazole for models of the N-(beta-D-glucopyranosyl)-1,2,4-triazolecarboxamides, quantum mechanics/molecular mechanics calculations and modeling. No inhibition by 3b and 4b | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | Oryctolagus cuniculus | - |
[(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | P00489 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[(1->4)-alpha-D-glucosyl]n + phosphate | - |
Oryctolagus cuniculus | [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
glycogen phosphorylase b | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.7 | - |
D-glucose | pH and temperature not specified in the publication | Oryctolagus cuniculus |