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Literature summary for 2.4.1.1 extracted from

  • Kato, A.; Nasu, N.; Takebayashi, K.; Adachi, I.; Minami, Y.; Sanae, F.; Asano, N.; Watson, A.A.; Nash, R.J.
    Structure-activity relationships of flavonoids as potential inhibitors of glycogen phosphorylase (2008), J. Agric. Food Chem., 56, 4469-4473.
    View publication on PubMed
Search for more literature for 2.4.1.1

Application

Application Comment Organism
medicine glycogen phosphorylase inhibitory flavonoids have potential to contribute to the protection or improvement of control of diabetes type II Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
6-hydroxyluteolin
-
 Rattus norvegicus
hypolaetin
-
 Rattus norvegicus
isoscullarein
-
 Rattus norvegicus
luteolin
-
 Rattus norvegicus
quercetagetin noncompetitive Rattus norvegicus
quercetin
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male, Wistar
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen + glucose 1-phosphate
-
 Rattus norvegicus glycogen + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GP b
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0035
-
 quercetagetin pH 6.8, 25°C Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0097
-
 pH 6.8, 25°C Rattus norvegicus quercetagetin
0.0116
-
 pH 6.8, 25°C Rattus norvegicus 6-hydroxyluteolin
0.0157
-
 pH 6.8, 25°C Rattus norvegicus hypolaetin
0.0297
-
 pH 6.8, 25°C Rattus norvegicus luteolin
0.0335
-
 pH 6.8, 25°C Rattus norvegicus quercetin
0.0461
-
 pH 6.8, 25°C Rattus norvegicus isoscullarein