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Literature summary for 2.4.1.1 extracted from

  • Chen, J.; Gong, Y.; Liu, J.; Hua, W.; Zhang, L.; Sun, H.
    Synthesis and biological evaluation of novel pyrazolo[4,3-b]oleanane derivatives as inhibitors of glycogen phosphorylase (2008), Chem. Biodivers., 5, 1304-1312.
    View publication on PubMed
Search for more literature for 2.4.1.1

Inhibitors

Inhibitors Comment Organism Structure
1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus
4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
-
 Oryctolagus cuniculus
benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
benzyl pyrazolo[4,3-b]olean-12-en-28-oate
-
 Oryctolagus cuniculus
Caffeine
-
 Oryctolagus cuniculus
oleanolic acid
-
 Oryctolagus cuniculus
pyrazolo[4,3-b]olean-12-en-28-oic acid
-
 Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Synonyms

Synonyms Comment Organism
glycogen phosphorylase
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0099
-
 pH 7.2, 22°C Oryctolagus cuniculus pyrazolo[4,3-b]olean-12-en-28-oic acid
0.014
-
-
 Oryctolagus cuniculus oleanolic acid
0.0247
-
 pH 7.2, 22°C Oryctolagus cuniculus 4-oxo-4-[(pyrazolo[4,3-b]olean-12-en-28-yl)oxy]butanoic acid
0.0372
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-propanoylpyrazolo[4,3-b]olean-12-en-28-oic acid
0.0456
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl pyrazolo[4,3-b]olean-12-en-28-oate
0.0493
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-(methylsulfonyl)pyrazolo[4,3-b]olean-12-en-28-oic acid
0.0538
-
 pH 7.2, 22°C Oryctolagus cuniculus 1'-acetylpyrazolo[4,3-b]olean-12-en-28-oic acid
0.057
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-(carboxymethyl)pyrazolo[4,3-b]olean-12-en-28-oate
0.063
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-benzylpyrazolo[4,3-b]olean-12-en-28-oate
0.0999
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-methylpyrazolo[4,3-b]olean-12-en-28-oate
0.111
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-[(ethoxycarbonyl)methyl]pyrazolo[4,3-b]olean-12-en-28-oate
0.114
-
 pH 7.2, 22°C Oryctolagus cuniculus Caffeine
0.132
-
 pH 7.2, 22°C Oryctolagus cuniculus benzyl 1'-(2,4-dichlorobenzyl)pyrazolo[4,3-b]olean-12-en-28-oate