Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.1 extracted from

  • Chen, J.; Liu, J.; Zhang, L.; Wu, G.; Hua, W.; Wu, X.; Sun, H.
    Pentacyclic triterpenes. Part 3: Synthesis and biological evaluation of oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase (2006), Bioorg. Med. Chem. Lett., 16, 2915-2919.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,3-dihydroisooxazolyl oleanolic acid benzyl ester 50% inhibition at 0.0196 mM Oryctolagus cuniculus
2-hydroxymethenyl oleanonic acid benzyl ester 50% inhibition at 0.0063 mM Oryctolagus cuniculus
benzyl (2Z,5xi,8alpha,9xi,10alpha,14beta,17alpha,18alpha)-2-[[(2,4-dichlorobenzyl)oxy]imino]-3-oxoolean-12-en-28-oate 50% inhibition at 0.008 mM Oryctolagus cuniculus
oleanolic acid 50% inhibition at 0.014 mM Oryctolagus cuniculus
oleanolic acid 3-O-[(2E)-3-(4-chlorophenyl)acrylic acid] ester 50% inhibition at 0.0033 mM Oryctolagus cuniculus
oleanolic acid 3-O-[(2E)-3-(4-methoxyphenyl)acrylic acid] ester 50% inhibition at 0.0169 mM Oryctolagus cuniculus
oleanonic acid 50% inhibition at 0.0179 mM Oryctolagus cuniculus
oleanonic acid 2,3-oxadiazole 50% inhibition at 0.0112 mM Oryctolagus cuniculus
oleanonic acid 3-oxime 50% inhibition at 0.0208 mM Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen + alpha-D-glucose 1-phosphate
-
Oryctolagus cuniculus glycogen + phosphate
-
?