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Literature summary for 2.3.3.8 extracted from

  • Icard, P.; Wu, Z.; Fournel, L.; Coquerel, A.; Lincet, H.; Alifano, M.
    ATP citrate lyase A central metabolic enzyme in cancer (2020), Cancer Lett., 471, 125-134 .
    View publication on PubMed
Search for more literature for 2.3.3.8

General Stability

General Stability Organism
activity is stabilized by acetylation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bempedoic acid
-
 Homo sapiens
Hydroxycitrate
-
 Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
480000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + citrate + CoA Homo sapiens
-
 ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P53396
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation the enzyme is activated by acetylation at lysine residues 540, 546, and 554 Homo sapiens
phosphoprotein the enzyme is activated by phosphorylation Homo sapiens
ubiquitination the enzyme is degraded by ubiquitinylation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + citrate + CoA
-
 Homo sapiens ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?

Subunits

Subunits Comment Organism
tetramer the tetramer comprises four identical subunits, each resulting from the fusion of N-terminal citryl-CoA synthetase module and the catalytic C-terminal citryl-CoA lyase domain Homo sapiens

Synonyms

Synonyms Comment Organism
ACLY
-
 Homo sapiens
ATP citrate lyase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens overexpressed in many cancers. ACLY transcription is promoted by SREBP1 up

General Information

General Information Comment Organism
metabolism the enzyme links energy metabolism provided by catabolic pathways to biosynthesis. ACLY plays a pivotal role in cancer metabolism through the potential deprivation of cytosolic citrate, a process promoting glycolysis through the enhancement of the activities of PFK 1 and 2 with concomitant activation of oncogenic drivers such as PI3K/AKT which activate ACLY and the Warburg effect in a feed-back loop Homo sapiens