Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | high glucose promotes ATP-citrate lyase nuclear translocation | Mus musculus | 5829 | - |
nucleus | high glucose promotes ATP-citrate lyase nuclear translocation | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | Mus musculus | - |
ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91V92 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mesangial cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | - |
Mus musculus | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACL | - |
Mus musculus |
ATP-citrate lyase | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | high glucose upregulates ATP-citrate lyase expression | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme plays a critical role in epigenetic regulation of diabetic renal fibrosis. It is essential for high glucose-induced histone hyperacetylation and fibrogenic gene upregulation in mesangial cells | Mus musculus |