Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Aspergillus niger |
Protein Variants | Comment | Organism |
---|---|---|
H305A | inactive mutant of isoform Acl1 | Aspergillus niger |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Aspergillus niger | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphate + acetyl-CoA + oxaloacetate | Aspergillus niger | - |
ATP + citrate + CoA | - |
? | |
ADP + phosphate + acetyl-CoA + oxaloacetate | Aspergillus niger ATCC 1015 | - |
ATP + citrate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus niger | - |
- |
- |
Aspergillus niger ATCC 1015 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography | Aspergillus niger |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphate + acetyl-CoA + oxaloacetate | - |
Aspergillus niger | ATP + citrate + CoA | - |
? | |
ADP + phosphate + acetyl-CoA + oxaloacetate | - |
Aspergillus niger ATCC 1015 | ATP + citrate + CoA | - |
? | |
additional information | only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein | Aspergillus niger | ? | - |
? | |
additional information | only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein | Aspergillus niger ATCC 1015 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACL1 | isoform | Aspergillus niger |
ACL2 | isoform | Aspergillus niger |
ACLY | - |
Aspergillus niger |
ATP-citrate lyase | - |
Aspergillus niger |
General Information | Comment | Organism |
---|---|---|
physiological function | isoforms Acl1 and Acl2 coordinately modulate the cytoplasmic acetyl-CoA levels to regulate growth, development, and citric acid synthesis in Aspergillus niger | Aspergillus niger |