Literature summary for 2.3.3.8 extracted from

MacDonald, M.J.; Hasan, N.M.; Longacre, M.J.
Studies with leucine, beta -hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion (2008), Biochim. Biophys. Acta, 1780, 966-972.

Search for more literature for 2.3.3.8

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
INS-1 cell	ATP citrate lyase-deficient INS-1 cells, which are unable to convert citrate into cytosolic acetyl-CoA, insulin release by 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid is decreased and adding beta-hydroxybutyrate or alpha-ketoisocaproate, which increases mitochondrial acetoacetate, normalizes 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid-induced insulin release	Rattus norvegicus	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)