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Literature summary for 2.3.3.8 extracted from

  • Michno, A.; Skibowska, A.; Raszeja-Specht, A.; Cwikowska, J.; Szutowicz, A.
    The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus (2004), Metabolism, 53, 66-72.
    View publication on PubMed

Application

Application Comment Organism
medicine diabetic patients in resting conditions and after activation with thrombin, show higher enzyme activity than controls, accompanied by increased pyruvate dehydrogenase activity, acetyl-CoA content, and thrombin-evoked malonyl dialdehyde synthesis. Activation of diabetic platelets causes 2 times greater release of acetyl-CoA from their mitochondria than in controls Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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patients suffering diabetes
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