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Literature summary for 2.3.3.6 extracted from

  • Rabin, R.; Salomon, I.I.; Bleiweis, A.S.; Carlin, J.; Ajl, S.J.
    Metabolism of ethylmalic acids by Pseudomonas aeruginosa (1968), Biochem. J., 7, 377-389.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
D-leucine weak Pseudomonas aeruginosa
L-isoleucine weak Pseudomonas aeruginosa
L-leucine 50% inhibition Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ in the absence of Mg2+ product is formed to an extent of 64% in the complete reaction Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + 2-ketoisovalerate
-
Pseudomonas aeruginosa ?
-
?
acetyl-CoA + H2O + 2-ketovalerate
-
Pseudomonas aeruginosa (R)-2-(n-propyl)-malate + CoA
-
?
acetyl-CoA + H2O + 2-oxobutanoate
-
Pseudomonas aeruginosa (R)-2-ethylmalate + CoA
-
ir
acetyl-CoA + H2O + pyruvate
-
Pseudomonas aeruginosa ?
-
?
additional information not: 2-ketocaproate and 2-ketoisocaproate Pseudomonas aeruginosa ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Pseudomonas aeruginosa

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
product formation doubled between pH 6.0 and 6.5, but there is a broud shoulder of activity between pH 6.5 and 7.5 Pseudomonas aeruginosa